From her upside-down house, the eccentric Mrs. Piggle-Wiggle issues to parents her marvelous cures for such common children's diseases as Won't-Put-Away-Toys-itis, Answerbackism, and Fighter-Quarrelitis.
Mrs. Piggle-Wiggle is back with special cures for the not truthful, the pet forgetter, the fraidy-cat, the destructive child, and the child who continually says, "I can't find it."
Seven families are helped out by Mrs. Piggle-Wiggle's magic cures when they are faced with thought-you-saiders, tattletalers, bad table manners, interrupters, heedless breakers, never-want-to-go-to-schoolers, and waddle-I-doers.
Two orphaned sisters are sent to live at a boarding home run by the cruel and greedy Mrs. Monday, where they dream about someday having enough to eat and being able to experience a real Christmas.